Ribosomal protein L1



Ribosomal protein L1 (RPL1) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to 23S or 28S RRNA. In the archaea family it is named L1P. The images at the left and at the right correspond to one representative RPL1, i.e. the crystal structure of Ribosomal protein L1 from Thermus thermophilus (2xg0, chain C).

RPL1
2oum, 2ov7 - TtRPL1 domain 1 – Thermus thermophilus

2hw8, 1zho - TtRPL1+mRNA fragment

1ad2 – TtRPL1 (mutant)

1u63 - MjRPL1P+mRNA fragment – Methanocaldococcus jannaschii

1i2a, 1cjs - MjRPL1P

1dwu - RPL1 – Methanococcus thermolithotrophicus

1mzp – RPL1P+23S RRNA fragment – Sulfolobus acidocaldarius

2vpl - TtRPL1 residues 2-68 160-229+mRNA fragment

L1 in 50S subunit+RNA
2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL1 in 50S subunit+RNA fragments

2x9s, 2x9u, 3kni, 3knk, 3knm, 3kno, 2wrj, 2wrl, 2wro, 2wrr, 3hux, 3huz, 2wh2, 2wh4, 2wdi, 2wdj, 2wdl, 2wdn, 1vsp, 2v47, 2v49, 1vsa, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 1giy, 2y0v, 2y0x, 2y0z, 2y11, 2y13, 2y15, 2y17, 2y19, 3pyo, 3pyr, 3pyt, 3pyv -  TtRPL1 in 50S subunit+5S RRNA+23S RRNA

3fin - TtRPL1 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

2wwq – EcRPL1 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli

3e1b, 3e1d, 1vor, 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny - EcRPL1P in 50S subunit+5S RRNA+23S RRNA

3fik, 2gya, 2gyc - EcRPL1 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

3kcr - EcRPL1 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase

2rdo - EcRPL1 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM

3bbo - RPL1 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach

L1 in 60S subunit
3jyw - RPL1 in 60S subunit – Thermomyces lanuginosus – Cryo-EM

2ftc - RPL1 in 60S subunit+16S RRNA - bovine

1s1h, 1s1i - yRPL1 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast

L1 in part of the large ribosomal subunit
487d – RPL1+RPL2+RPL6+RPL9+RPL11+RPL14+RPL25 - Cryo_EM

2noq – RPL1+RPL11+RPS5+18S RRNA+Cricket paralysis virus IRES RNA

L1 in large + small ribosomal subunit
1ml5 - EcRPL1 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM

L1 in 50S subunit + various proteins
2om7 – TtRPL1+RPS2+RPS12+tRNA+16S RRNA fragments+23S RRNA fragments+EF-G

L1 in 50S subunit + antibiotic
3pio, 3pip - RPL1 in 50S subunit+5S RRNA+23SRRNA+antibiotic - Deinococcus radiodurans